183 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
This study utilizes confocal microscopy and fluorescently tagged VP40 mutants to characterize the subcellular distribution and trafficking pathways of the Ebola virus matrix protein, revealing how membrane-binding-dependent aggregation and interactions with host secretory machinery drive the assembly of the viral matrix layer.
The paper introduces LowDoseWizard, a modular and guided workflow within SerialEM that significantly reduces the time and expertise required to standardize low-dose cryo-TEM microscope setup, enabling rapid configuration that supports high-resolution single-particle data collection.
This study identifies cationic peptides derived from the HPV16 L1 capsid protein as highly efficient cell-penetrating agents capable of delivering cargo into cells via heparan sulfate-mediated endocytosis and exhibiting potent antiviral activity against high-risk HPV types by blocking viral entry.
This study demonstrates that using CRISPR/Cas9 technology to knock out the β-D-N-acetylhexosaminidase (β-hex) gene in tomato plants successfully extends fruit shelf life and firmness without compromising quality or introducing transgenic elements.
This paper proposes and provides evidence that linear developmental trajectories in cells are driven by and linked to concurrent epigenomic and transcriptomic oscillations, suggesting a fundamental mechanism for encoding molecular time and ensuring developmental robustness.
The study reveals that during bacterial infection, the caspase Dredd cleaves the autophagy receptor-bound IKK complex subunit Kenny to remove its LC3-interacting region, thereby uncoupling the complex from selective autophagy-mediated repression and enabling robust NF-κB-dependent innate immune responses.
This study demonstrates that lauric acid exhibits significant antiviral activity against Dengue virus serotype 2 by inhibiting viral RNA replication and translation in a replicon assay, although its therapeutic potential is currently limited by cytotoxicity at effective concentrations.
This paper presents a modular, cost-effective, and open-source cryogenic fluorescence microscope designed for super-resolution correlative light and electron microscopy that achieves high localization precision and stability while minimizing ice contamination.
This paper introduces EntDetect, an open-source computational tool and accompanying webserver designed to identify non-covalent lasso entanglements (NCLEs) in protein structures and simulation trajectories, enabling the detection of misfolded states and integration with mass spectrometry data to advance the study of protein topology and misfolding.
This paper argues that lethal mutagenesis sets an upper bound on mutation rates and demonstrates that coding genome size, body mass, generation time, and temperature collectively explain over 90% of the variation in mutation rates across the Tree of Life, indicating that organisms with larger genomes and longer lifespans have evolved novel mechanisms to minimize germline mutations.